ABSTRACT
Open field activity was studied in Wistar rats. Animals with low scores of ambulatory and rearing behaviours were grouped as hypoactive and those with high scores as hyperactive. Acquisition of active avoidance learning in a shuttle box was studied in the two groups. Hyperactive rats in contrast to hypoactive rats showed a better acquisition of avoidance learning. Learning was suppressed in both groups by domperidone, but was facilitated by immobilisation stress in the hypoactive group only. The two groups did not differ in the basal and stress evoked heart rates. These observations suggest that immobilisation stress favours enhancement of the dopaminergic related behaviour like avoidance learning in hypoactive rats.
Subject(s)
Animals , Avoidance Learning/physiology , Behavior, Animal/physiology , Dopamine/physiology , Exploratory Behavior/physiology , Heart Rate/physiology , Hyperkinesis/physiopathology , Male , Motor Activity/physiology , Rats , Rats, Wistar , Restraint, Physical , Stress, Physiological/physiopathologyABSTRACT
Del estudio retrospectivo de 147 historias clinicas (abril 1981 a abril 1991), se aislan 30 casos de sindrome hipercinetico en niños comprendidos entre 1 y 12 años de edad. Se analizan las variables de sexo, antecedentes eredologicos y personales, rendimiento escolar, sintomatologia basica y asociada al sindrome, asi como las anomalias registradas en el estudio electroencefalografico de 21 niños, ademas el tratamiento afectuado. no existen antecedentes de studio similar, en nuestro medio. Se debe alertar hacia esta patologia a traves de la actividad profesional pediatrica para detectar precozmente el sindrome y asumir la terapeutica que el caso requiere. Por los resultados del trbajo, la prevencion a traves de un cuidado pre y perinatal que garantice un parto normal, son aconsejables asi como el tratamiento de los progenitores que presentan rasgos de personalidad anormales y consumo abusivo o dependencia a bebidas alcoholicas.